Dr. Laurie Marzell N.D., N.C.M.P.

 Naturopathic physician
Certified Menopause Practitioner



Low Dose Naltrexone: Using An Old Time Drug To Stop Your Body From Attacking Itself


The Story of Naltrexone: Happy Hormones to the Rescue

How would you like to feel happier, have less pain and inflammation and prevent cancer to boot?  Sounds too good to be true? Introducing an old drug with some new tricks.  Naltrexone was originally approved years ago to treat drug addiction.  It worked by blocking the endorphin(happy hormone) receptors so the addict could not obtain the “high” from the drug of choice.  That sounds terrible, you may think.  I want my happy hormones!! (You will have them!)

One of the doctors involved in using naltrexone, started wondering about how it may affect the immune system as well as its effects for drug addicts.  Dr. Bihari started experimenting with smaller doses of naltrexone which only block the endorphin receptors for 3-6 hours.  He discovered by using tiny doses of naltrexone, the body responded to the block by increasing production of endorphins. Since the endorphin production normally peaks during the night, if a dose of naltrexone is taken before bed, the endorphin production can triple during the night.  While this can produce some wacky dreams, it can also increase the endorphin level to last for the rest of the day.

In addition to the mental piece of mind, endorphins and metenkephalins, which are also produced, have a powerful effect on the immune system.  For those who have autoimmune diseases, such as rheumatoid arthritis, psoriasis, Crohn’s disease, or thyroiditis, endorphins may calm an overactive immune attack.  This settling of the immune system may be evident in decreased antibodies to the tissue attacked, and most certainly will be evident in the relief of symptoms patients report.  One study in theAmerican Journal of Gastroenterology reported an improvement in Crohn’s disease (inflammatory bowel disease) of 89% with low dose naltrexone.

Low dose naltrexone has shown improvement in treating fibromyalgia, and even some cases of autism.  One of the most impressive studies I have found was the reversal of brain lesions in multiple sclerosis patients.

How does this work?  There are endorphin or “opioid” receptors on nerve, immune and tumor cells.  B endorphins also shift the types of immune cells (Th1 to Th2) to decrease inflammation.  Met-5-enkephalins are present in bone and joint tissues and levels are decreased in arthritic conditions.  B-endorphins have an anti-inflammatory effect on joint cartilage.

What about cancer cells?  Met-5-enkephalins will actually hook into receptors on cancer cells and stimulate them to kill themselves.  Case studies of a variety of cancers have been published by Burt Berkson, M.D.  Of particular interest, is the response he has demonstrated in very difficult cancers, such as pancreatic.  Although the case studies are not the same as large double blinded clinical studies, the results are certainly noteworthy, especially since PET scans of the regression of cancers are included.

Low dose naltrexone may be considered a miracle drug.  I always remind patients that the miracle is really not from the naltrexone, it is only a stimulant for the miracle of the person’s own hormones and their interactions with the immune system.

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